Teams trending in opposite directions will meet when the undefeated Buffalo Bills face the winless Jacksonville Jaguars in the first of two Monday Night Football games. Buffalo defeated Miami, 31-10 in Week 2, while Jacksonville dropped an 18-13 decision to Cleveland. The Jaguars (0-2), who have gone 9-8 the past two seasons, are 6-4 on the road since the beginning of last year. The Bills (2-0), who have won the AFC East four seasons in a row, are 8-3 at home since the start of 2023.
Kickoff from Highmark Stadium in Orchard Park, N.Y., is set for 7:30 p.m. ET. The Bills are 5.5-point favorites in the latest Jaguars vs. Bills odds, while the over/under for total points scored is 45.5. Before making any Bills vs. Jaguars picks, be sure to see the NFL predictions and betting advice from SportsLine’s proven computer model.
The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 3 of the 2024 NFL season on an incredible 187-130 run on top-rated NFL picks that dates back to the 2017 season. It is also on a 41-22 roll on top-rated NFL picks since Week 7 of 2022.
The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick’em players four times during that span. Anyone who has followed it is way up.
Now, the model has set its sights on Jaguars vs. Bills and just locked in its picks and NFL predictions. You can head to SportsLine now to see the model’s picks. Here are several NFL odds and NFL betting lines for the spread, money line and over/under for Bills vs. Jaguars:
- Jaguars vs. Bills spread: Buffalo -5.5
- Jaguars vs. Bills over-under: 45.5 points
- Jaguars vs. Bills money line: Buffalo -250, Jacksonville +203
- JAC: Jaguars have covered the third-quarter spread in 12 of their last 17 games (+6.75 units)
- BUF: Bills have hit the third-quarter money line in 11 of their last 19 games
- Jaguars vs. Bills picks: See picks at SportsLine
Why you should back the Bills
Quarterback Josh Allen passed for 139 yards and a touchdown with no interceptions for a 107.1 rating in Week 2, his third week in a row with a 100-plus rating and a passing touchdown. He had 373 total yards and three total touchdowns in the last meeting with Jacksonville. Allen has 40 career games, including the playoffs, with a passing and rushing touchdown, the second-most in NFL history (Cam Newton had 46). Allen has 300 or more passing yards and three-plus TDs for a 105 or better rating in four of seven Monday Night Football starts.
Running back James Cook had a solid game in the win over Miami. He had 95 yards from scrimmage (78 rushing and 17 receiving) and three touchdowns (two rushing and one receiving), the second-most in the NFL in Week 2. Cook has 100 or more scrimmage yards in four of his past five games at home. He will look for his fourth prime time game in a row at home with 70-plus scrimmage yards. See which team to pick here.
Why you should back the Jaguars
Fourth-year veteran quarterback Trevor Lawrence has thrown for over 4,000 yards the last two seasons, but is off to a bit of a slow start this year. In two games, Lawrence has completed just 26 of 51 passes (51%) for 382 yards. He has also rushed for 53 yards on three carries, including a season-high 33-yarder. In 52 career games, Lawrence has completed 63.4% of his passes for 12,152 yards and 59 touchdowns. He has been picked off 39 times.
Lawrence’s top target so far this season is first-round draft pick Brian Thomas Jr. The wide receiver leads the team with 141 yards receiving on six catches (23.5 average) and one score. He has two explosive catches of 20 or more yards, including a long of 66 yards. He has also converted five first downs. See which team to pick here.
How to make Jaguars vs. Bills picks
SportsLine’s model is leaning Over on the total, projecting 50 combined points. It has also generated an against-the-spread pick that hits in over 60% of simulations. You can only get the NFL model’s picks at SportsLine.
So who wins Jaguars vs. Bills on Monday Night Football, and which side of the spread cashes in more than 60% of simulations? Visit SportsLine now to see which side of the Jaguars vs. Bills spread to jump on, all from the advanced model that is up well over $7,000 on its NFL picks, and find out.
